Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Tjp1  tight junction protein 1   (Synonyms: ZO1, ZO-1)
Results	Reference
1	J:290418 Ashokkumar D, Zhang Q, Much C, Bledau AS, Naumann R, Alexopoulou D, Dahl A, Goveas N, Fu J, Anastassiadis K, Stewart AF, Kranz A, MLL4 is required after implantation, whereas MLL3 becomes essential during late gestation. Development. 2020 Jun 17;147(12):dev186999
1	J:333370 Bebelman MP, Bovyn MJ, Mayer CM, Delpierre J, Naumann R, Martins NP, Honigmann A, Kalaidzidis Y, Haas PA, Zerial M, Hepatocyte apical bulkheads provide a mechanical means to oppose bile pressure. J Cell Biol. 2023 Apr 3;222(4)
1	J:169219 Blitzer AL, Panagis L, Gusella GL, Danias J, Mlodzik M, Iomini C, Primary cilia dynamics instruct tissue patterning and repair of corneal endothelium. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2819-24
1	J:228786 Charrier LE, Loie E, Laprise P, Mouse Crumbs3 sustains epithelial tissue morphogenesis in vivo. Sci Rep. 2015;5:17699
1*	J:288446 Christians A, Weiss AC, Martens H, Klopf MG, Hennies I, Haffner D, Kispert A, Weber RG, Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies. Hum Mol Genet. 2020 May 8;29(7):1192-1204
1	J:255775 Connell M, Chen H, Jiang J, Kuan CW, Fotovati A, Chu TL, He Z, Lengyell TC, Li H, Kroll T, Li AM, Goldowitz D, Frappart L, Ploubidou A, Patel MS, Pilarski LM, Simpson EM, Lange PF, Allan DW, Maxwell CA, HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development. Elife. 2017 Oct 10;6:e28672
1*	J:147670 Done SC, Takemoto M, He L, Sun Y, Hultenby K, Betsholtz C, Tryggvason K, Nephrin is involved in podocyte maturation but not survival during glomerular development. Kidney Int. 2008 Mar;73(6):697-704
1	J:234059 Elias BC, Das A, Parekh DV, Mernaugh G, Adams R, Yang Z, Brakebusch C, Pozzi A, Marciano DK, Carroll TJ, Zent R, Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development. J Cell Sci. 2015 Dec 1;128(23):4293-305
1	J:161201 Gao N, Kaestner KH, Cdx2 regulates endo-lysosomal function and epithelial cell polarity. Genes Dev. 2010 Jun 15;24(12):1295-305
1*	J:226326 Greenlees R, Mihelec M, Yousoof S, Speidel D, Wu SK, Rinkwitz S, Prokudin I, Perveen R, Cheng A, Ma A, Nash B, Gillespie R, Loebel DA, Clayton-Smith J, Lloyd IC, Grigg JR, Tam PP, Yap AS, Becker TS, Black GC, Semina E, Jamieson RV, Mutations in SIPA1L3 cause eye defects through disruption of cell polarity and cytoskeleton organization. Hum Mol Genet. 2015 Oct 15;24(20):5789-804
1	J:103919 Gresh L, Bourachot B, Reimann A, Guigas B, Fiette L, Garbay S, Muchardt C, Hue L, Pontoglio M, Yaniv M, Klochendler-Yeivin A, The SWI/SNF chromatin-remodeling complex subunit SNF5 is essential for hepatocyte differentiation. EMBO J. 2005 Sep 21;24(18):3313-24
1	J:317245 Hara S, Tsujikawa M, Maruyama K, Nishida K, STAT3 signaling maintains homeostasis through a barrier function and cell survival in corneal endothelial cells. Exp Eye Res. 2019 Feb;179:132-141
1	J:255415 He M, Ye W, Wang WJ, Sison ES, Jan YN, Jan LY, Cytoplasmic Cl(-) couples membrane remodeling to epithelial morphogenesis. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11161-E11169
1	J:78912 Hellstrom M, Gerhardt H, Kalen M, Li X, Eriksson U, Wolburg H, Betsholtz C, Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol. 2001 Apr 30;153(3):543-53
1*	J:273083 Joseph DB, Chandrashekar AS, Abler LL, Chu LF, Thomson JA, Vezina CM, Epithelial DNA methyltransferase-1 regulates cell survival, growth and maturation in developing prostatic buds. Dev Biol. 2019 Mar 15;447(2):157-169
1	J:266265 Kishimoto K, Tamura M, Nishita M, Minami Y, Yamaoka A, Abe T, Shigeta M, Morimoto M, Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus. Nat Commun. 2018 Jul 19;9(1):2816
1	J:71581 Kostka G, Giltay R, Bloch W, Addicks K, Timpl R, Fassler R, Chu ML, Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice. Mol Cell Biol. 2001 Oct;21(20):7025-34
1*	J:180113 Lachke SA, Higgins AW, Inagaki M, Saadi I, Xi Q, Long M, Quade BJ, Talkowski ME, Gusella JF, Fujimoto A, Robinson ML, Yang Y, Duong QT, Shapira I, Motro B, Miyoshi J, Takai Y, Morton CC, Maas RL, The cell adhesion gene PVRL3 is associated with congenital ocular defects. Hum Genet. 2012 Feb;131(2):235-50
1	J:270789 Lee S, Cieply B, Yang Y, Peart N, Glaser C, Chan P, Carstens RP, Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity. Cell Rep. 2018 Nov 27;25(9):2417-2430.e5
1	J:190580 Lei Z, Maeda T, Tamura A, Nakamura T, Yamazaki Y, Shiratori H, Yashiro K, Tsukita S, Hamada H, EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins. Dev Biol. 2012 Nov 15;371(2):136-45
1	J:125901 McLaughlin ME, Kruger GM, Slocum KL, Crowley D, Michaud NA, Huang J, Magendantz M, Jacks T, The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3261-6
1*	J:218202 Mellas RE, Kim H, Osinski J, Sadibasic S, Gronostajski RM, Cho M, Baker OJ, NFIB Regulates Embryonic Development of Submandibular Glands. J Dent Res. 2015 Feb;94(2):312-9
1*	J:201080 Nelson DA, Manhardt C, Kamath V, Sui Y, Santamaria-Pang A, Can A, Bello M, Corwin A, Dinn SR, Lazare M, Gervais EM, Sequeira SJ, Peters SB, Ginty F, Gerdes MJ, Larsen M, Quantitative single cell analysis of cell population dynamics during submandibular salivary gland development and differentiation. Biol Open. 2013 May 15;2(5):439-47
1	J:83341 Nitta T, Hata M, Gotoh S, Seo Y, Sasaki H, Hashimoto N, Furuse M, Tsukita S, Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol. 2003 May 12;161(3):653-60
1	J:90052 Okabe N, Ozaki-Kuroda K, Nakanishi H, Shimizu K, Takai Y, Expression patterns of nectins and afadin during epithelial remodeling in the mouse embryo. Dev Dyn. 2004 May;230(1):174-86
1	J:308917 Panicker N, Coutman M, Lawlor-O'Neill C, Kahl RGS, Roselli S, Verrills NM, Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55alpha, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development. Front Cell Dev Biol. 2020;8:358
1	J:201523 Ray S, Foote HP, Lechler T, beta-Catenin protects the epidermis from mechanical stresses. J Cell Biol. 2013 Jul 8;202(1):45-52
1	J:297252 Seymour PA, Collin CA, Egeskov-Madsen AR, Jorgensen MC, Shimojo H, Imayoshi I, de Lichtenberg KH, Kopan R, Kageyama R, Serup P, Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors. Dev Cell. 2020 Mar 23;52(6):731-747.e8
1	J:169693 Silberschmidt D, Rodriguez-Mallon A, Mithboakar P, Cali G, Amendola E, Sanges R, Zannini M, Scarfo M, De Luca P, Nitsch L, Di Lauro R, De Felice M, In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1. BMC Dev Biol. 2011;11:9
1*	J:80178 Simon AM, McWhorter AR, Vascular Abnormalities in Mice Lacking the Endothelial Gap Junction Proteins connexin37 and connexin40. Dev Biol. 2002 Nov 15;251(2):206-20
1	J:134686 Srinivasan K, Roosa J, Olsen O, Lee SH, Bredt DS, McConnell SK, MALS-3 regulates polarity and early neurogenesis in the developing cerebral cortex. Development. 2008 May;135(10):1781-90
1	J:154910 Sugiyama Y, Akimoto K, Robinson ML, Ohno S, Quinlan RA, A cell polarity protein aPKClambda is required for eye lens formation and growth. Dev Biol. 2009 Dec 15;336(2):246-56
1	J:239794 Szymaniak AD, Mahoney JE, Cardoso WV, Varelas X, Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap. Dev Cell. 2015 Aug 10;34(3):283-96
1*	J:147958 Vandenberg AL, Sassoon DA, Non-canonical Wnt signaling regulates cell polarity in female reproductive tract development via van gogh-like 2. Development. 2009 May;136(9):1559-70
1	J:73084 Vasioukhin V, Bowers E, Bauer C, Degenstein L, Fuchs E, Desmoplakin is essential in epidermal sheet formation. Nat Cell Biol. 2001 Dec;3(12):1076-85
1	J:302296 Vong KI, Ma TC, Li B, Leung TCN, Nong W, Ngai SM, Hui JHL, Jiang L, Kwan KM, SOX9-COL9A3-dependent regulation of choroid plexus epithelial polarity governs blood-cerebrospinal fluid barrier integrity. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2009568118
1*	J:181271 Westmoreland JJ, Drosos Y, Kelly J, Ye J, Means AL, Washington MK, Sosa-Pineda B, Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation. Dev Dyn. 2012 Mar;241(3):583-94
1	J:206750 Whiteman EL, Fan S, Harder JL, Walton KD, Liu CJ, Soofi A, Fogg VC, Hershenson MB, Dressler GR, Deutsch GH, Gumucio DL, Margolis B, Crumbs3 is essential for proper epithelial development and viability. Mol Cell Biol. 2014 Jan;34(1):43-56